Curcumin exerts a protective effect against obesity and liver injury induced by an atherogenic diet

Background: Curcumin (Cur) is a natural yellow polyphenol extracted from the turmeric rhizome (Curcuma longa). Cur known for its potential therapeutic properties as an analgesic, anti-inflammatory, antioxidant, antimicrobial, hepatoprotective, and anti-mutagenic, although some of these biological activities remain unproven. Epidemiological studies have shown positive relationship between high-fat diets diet-related chronic diseases. We hypothesized that adverse effects consuming atherogenic or (AD) can be ameliorated by supplementation. Using experimental model rats, this study investigated significance when it given supplement in AD.Methods: Healthy adult Wistar rats were randomly assigned to one three groups. Controls (C) received standard diet fed with AD AD+Cur 5 weeks. (100 mg/kg body weight) was orally daily, plus piperine (5 weight). The effect supplementation studied on zoometrics, visceral fat content, serum lipids profile, hepatosteatosis, liver function oxidative status. Results: Diets did not alter energy consumption. As compared other groups, group showed lower total percentage perirenal, mesenteric, pelvic fat, weight gain (P< 0.05). Serum cholesterol (P<0.0001), non-HDL-C (P<0.0001) levels significantly higher groups C. triglycerides HDL-C remained similar among (P>0.05). induced injury macrovesicular steatosis portal inflammation. presented microvesicular no inflammation, achieving lowest level alanine aminotransferase (ALT; P<0.0001) reductions aspartate (AST; P<0.0001). Liver homogenates reduced dichlorofluorescein diacetate (DCFH-DA) oxidation rate 25 % deferoxamine superoxide dismutase inhibited DCFH-DA. Conclusion: dietary protective against obesity but cardioprotective ability unproved. may develop promising agent diseases stress. This provides supporting evidence confirm beneficial curcumin point view functional food science. Keywords: curcumin, injury, ROS, diet,